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西地那非在伦敦夜总会的大量滥用情况。

Significant Misuse of Sildenafil in London Nightclubs.

作者信息

Chan Wui Ling, Wood David Michael, Dargan Paul Ivor

机构信息

a Emergency Department, Tan Tock Seng Hospital , Singapore.

b Guy's and St Thomas' NHS Foundation Trust, Clinical Toxicology, St Thomas' Hospital , London , United Kingdom.

出版信息

Subst Use Misuse. 2015;50(11):1390-4. doi: 10.3109/10826084.2015.1013135. Epub 2015 Oct 6.

Abstract

BACKGROUND

There is anecdotal evidence of misuse of erectile dysfunction medication, particularly to counteract some of the unwanted effects of recreational drugs on erectile function. However, there is little data from the United Kingdom (UK).

AIM

To evaluate the prevalence of sildenafil misuse in a UK population that has previously been shown to have high recreational drug use.

DESIGN

Questionnaire survey.

METHODS

Individuals attending nightclubs catering for the men who have sex with men (MSM) community in South London were asked about lifetime and last year use of recreational drugs and sildenafil.

RESULTS

313 individuals were surveyed over four nights in 2013: 282 (90.1%) were males and 248 (79.2%) were MSM. Last year use of recreational drugs was high: mephedrone (74.1%), cocaine (61.3%), MDMA/Ecstasy (59.2%), GHB/GBL (52.8%), cannabis (51.8%), and ketamine (50%). 136 (49.1%) MSM versus 6 (18.8%) non-MSM clubbers had misused sildenafil in the last year (p < .001). Amongst the MSM clubbers, 232 (93.5%) had heard of sildenafil, 161 (64.9%) reported misuse of sildenafil in their lifetime and 133 (53.6%) had misused sildenafil in the last year.

CONCLUSION

This study demonstrates a high prevalence of sildenafil misuse in a population who are heavy users of recreational drugs; it is not likely that this young population have underlying erectile dysfunction as a reason for legitimate sildenafil use. There is the potential for interaction with other recreational drugs used including cocaine and volatile nitrites. Further work is required in to determine the extent and reason for the misuse.

摘要

背景

有传闻称存在勃起功能障碍药物滥用的情况,尤其是用于抵消某些娱乐性药物对勃起功能产生的不良影响。然而,来自英国的数据很少。

目的

评估在先前已显示娱乐性药物使用量高的英国人群中,西地那非滥用的患病率。

设计

问卷调查。

方法

对伦敦南部为男同性恋群体服务的夜总会中的人员询问其终生及去年娱乐性药物和西地那非的使用情况。

结果

2013年四个晚上共调查了313人:282人(90.1%)为男性,248人(79.2%)为男同性恋者。去年娱乐性药物的使用率很高:甲氧麻黄酮(74.1%)、可卡因(61.3%)、摇头丸(59.2%)、γ-羟基丁酸/γ-丁内酯(52.8%)、大麻(51.8%)和氯胺酮(50%)。去年有136名(49.1%)男同性恋者与6名(18.8%)非男同性恋夜总会常客滥用了西地那非(p<0.001)。在男同性恋夜总会常客中,232人(93.5%)听说过西地那非,161人(64.9%)报告终生滥用过西地那非,133人(53.6%)去年滥用过西地那非。

结论

本研究表明在大量使用娱乐性药物的人群中西地那非滥用的患病率很高;这个年轻人群不太可能因潜在的勃起功能障碍而有合理使用西地那非的理由。存在与包括可卡因和挥发性亚硝酸盐在内的其他娱乐性药物相互作用的可能性。需要进一步开展工作以确定滥用的程度和原因。

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