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标志物:肌钙蛋白检测——风险分层与分层医学。

Biomarkers: Troponin testing--risk stratification to stratified medicine.

机构信息

Division of Cardiology, Department of Medicine and the Duke Clinical Research Institute, Duke University Medical Center, P.O. Box 17969, Durham, NC 27715, USA.

出版信息

Nat Rev Cardiol. 2015 Nov;12(11):625-6. doi: 10.1038/nrcardio.2015.157. Epub 2015 Oct 6.

DOI:10.1038/nrcardio.2015.157
PMID:26440981
Abstract

Among patients with diabetes mellitus and ischaemic heart disease, high-sensitivity testing effectively identified 39.3% of patients with elevated troponin levels who were at high 5-year risk of cardiovascular death, myocardial infarction, or stroke. Compared with optimal medical therapy, revascularization did not reduce ischaemic events among patients with elevated troponin levels.

摘要

在患有糖尿病和缺血性心脏病的患者中,高敏检测有效地确定了 39.3%的肌钙蛋白水平升高且 5 年心血管死亡、心肌梗死或中风风险较高的患者。与最佳药物治疗相比,血管重建并不能降低肌钙蛋白水平升高患者的缺血事件。

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本文引用的文献

1
Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes.稳定型缺血性心脏病和糖尿病中的肌钙蛋白与心脏事件
N Engl J Med. 2015 Aug 13;373(7):610-20. doi: 10.1056/NEJMoa1415921.
2
Variations in coronary artery disease secondary prevention prescriptions among outpatient cardiology practices: insights from the NCDR (National Cardiovascular Data Registry).门诊心脏病学实践中冠心病二级预防处方的差异:来自国家心血管数据注册库(NCDR)的见解
J Am Coll Cardiol. 2014 Feb 18;63(6):539-46. doi: 10.1016/j.jacc.2013.09.053. Epub 2013 Oct 30.
3
Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome.
敏感肌钙蛋白 I 检测在疑似急性冠脉综合征患者中的应用及其对再发心肌梗死和死亡的风险。
JAMA. 2011 Mar 23;305(12):1210-6. doi: 10.1001/jama.2011.338.
4
Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.高敏肌钙蛋白 T 检测与普通人群中心脏结构和死亡风险的相关性。
JAMA. 2010 Dec 8;304(22):2503-12. doi: 10.1001/jama.2010.1768.
5
Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults.采用敏感检测方法连续检测心脏肌钙蛋白 T 与老年人心力衰竭和心血管死亡率的关系。
JAMA. 2010 Dec 8;304(22):2494-502. doi: 10.1001/jama.2010.1708. Epub 2010 Nov 15.
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A randomized trial of therapies for type 2 diabetes and coronary artery disease.2型糖尿病与冠状动脉疾病治疗的随机试验
N Engl J Med. 2009 Jun 11;360(24):2503-15. doi: 10.1056/NEJMoa0805796. Epub 2009 Jun 7.
7
Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis.门诊心力衰竭患者心肌肌钙蛋白T升高的意义:一项前瞻性分析。
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8
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JAMA. 2001 Nov 21;286(19):2405-12. doi: 10.1001/jama.286.19.2405.
9
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