评估和稳定自闭症谱系障碍中的异常神经可塑性：经颅磁刺激的潜在作用。
Assessing and Stabilizing Aberrant Neuroplasticity in Autism Spectrum Disorder: The Potential Role of Transcranial Magnetic Stimulation.
作者信息
Desarkar Pushpal, Rajji Tarek K, Ameis Stephanie H, Daskalakis Zafiris Jeff
机构信息
Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto , Toronto, ON , Canada ; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health , Toronto, ON , Canada.
Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto , Toronto, ON , Canada ; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health , Toronto, ON , Canada ; Department of Psychiatry, The Hospital for Sick Children, University of Toronto , Toronto, ON , Canada ; Research Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health (CAMH) , Toronto, ON , Canada.
出版信息
Front Psychiatry. 2015 Sep 9;6:124. doi: 10.3389/fpsyt.2015.00124. eCollection 2015.
Exciting developments have taken place in the neuroscience research in autism spectrum disorder (ASD), and results from these studies indicate that brain in ASD is associated with aberrant neuroplasticity. Transcranial magnetic stimulation (TMS) has rapidly evolved to become a widely used, safe, and non-invasive neuroscientific tool to investigate a variety of neurophysiological processes, including neuroplasticity. The diagnostic and therapeutic potential of TMS in ASD is beginning to be realized. In this article, we briefly reviewed evidence of aberrant neuroplasticity in ASD, suggested future directions in assessing neuroplasticity using repetitive TMS (rTMS), and discussed the potential of rTMS in rectifying aberrant neuroplasticity in ASD.
自闭症谱系障碍（ASD）的神经科学研究取得了令人振奋的进展，这些研究结果表明，ASD患者的大脑与异常的神经可塑性有关。经颅磁刺激（TMS）已迅速发展成为一种广泛应用、安全且无创的神经科学工具，用于研究包括神经可塑性在内的各种神经生理过程。TMS在ASD中的诊断和治疗潜力正开始得到认识。在本文中，我们简要回顾了ASD中异常神经可塑性的证据，提出了使用重复经颅磁刺激（rTMS）评估神经可塑性的未来方向，并讨论了rTMS纠正ASD中异常神经可塑性的潜力。
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