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多胺精胺通过丝裂原活化蛋白激酶级联反应在拟南芥中诱导未折叠蛋白反应。

The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis.

作者信息

Sagor G H M, Chawla Pratima, Kim Dong W, Berberich Thomas, Kojima Seiji, Niitsu Masaru, Kusano Tomonobu

机构信息

Graduate School of Life Sciences, Tohoku University Sendai, Japan.

Biodiversity and Climate Research Center, Laboratory Center Frankfurt am Main, Germany.

出版信息

Front Plant Sci. 2015 Sep 10;6:687. doi: 10.3389/fpls.2015.00687. eCollection 2015.

DOI:10.3389/fpls.2015.00687
PMID:26442007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4565113/
Abstract

In Arabidopsis three basic region leucine zipper (bZIP) transcription factor genes, bZIP17, bZIP28, and bZIP60, play crucial roles in the unfolded protein response (UPR). Previously we found that bZIP60 is one of the spermine-induced genes. Consequently we further investigated the response of all the three bZIP genes to spermine. Expression of bZIP17, bZIP28, and bZIP60, and also their target genes was activated by spermine application as well as in plants with elevated endogenous spermine levels. Furthermore, spermine activated the splicing of the bZIP60 transcript mediated by the ribonuclease activity of inositol-requiring enzyme 1 and also recruited bZIP17 and bZIP60 proteins from endoplasmic reticulum to nucleus. We therefore propose that spermine is a novel UPR inducer. Moreover, induction of UPR by spermine required calcium-influx to the cytoplasm and the genes for mitogen-activated protein kinase kinase 9 (MKK9), mitogen-activated protein kinase 3 (MPK3) and MPK6. The result indicates that spermine-induced UPR is mediated by the MKK9-MPK3/MPK6 cascade in Arabidopsis.

摘要

在拟南芥中，三个碱性区域亮氨酸拉链（bZIP）转录因子基因bZIP17、bZIP28和bZIP60在未折叠蛋白反应（UPR）中发挥关键作用。此前我们发现bZIP60是精胺诱导基因之一。因此，我们进一步研究了这三个bZIP基因对精胺的反应。施用精胺以及在内源精胺水平升高的植物中，bZIP17、bZIP28和bZIP60及其靶基因的表达均被激活。此外，精胺激活了由肌醇需求酶1的核糖核酸酶活性介导的bZIP60转录本的剪接，还将bZIP17和bZIP60蛋白从内质网募集到细胞核。因此，我们提出精胺是一种新型的UPR诱导剂。此外，精胺诱导的UPR需要钙离子流入细胞质以及有丝分裂原激活蛋白激酶激酶9（MKK9）、有丝分裂原激活蛋白激酶3（MPK3）和MPK6的基因参与。结果表明，在拟南芥中精胺诱导的UPR是由MKK9 - MPK3/MPK6级联介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/2a62952efec0/fpls-06-00687-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/bdae07061c19/fpls-06-00687-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/887d11d2f161/fpls-06-00687-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/882d5e2cbf99/fpls-06-00687-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/43cac3e019ee/fpls-06-00687-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/edfb261f043b/fpls-06-00687-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/f42ab385f741/fpls-06-00687-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/d3334172104d/fpls-06-00687-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/2a62952efec0/fpls-06-00687-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/bdae07061c19/fpls-06-00687-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/887d11d2f161/fpls-06-00687-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/882d5e2cbf99/fpls-06-00687-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/43cac3e019ee/fpls-06-00687-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/edfb261f043b/fpls-06-00687-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/f42ab385f741/fpls-06-00687-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/d3334172104d/fpls-06-00687-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d5/4565113/2a62952efec0/fpls-06-00687-g008.jpg

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