奥昔哌汀对大鼠离体输精管的作用。
Effects of oxypertine on the isolated vas deferens of the rat.
作者信息
Miranda H
出版信息
Br J Pharmacol. 1978 Apr;62(4):515-8. doi: 10.1111/j.1476-5381.1978.tb07755.x.
1 The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic-anxiolytic drug. 2 Oxypertine (4.4 X 10(-10) M to 2.6 X 10(-5) M) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5-hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8). 3 Oxypertine (8.8 X 10(-9) M to 2.6 X 10(-5) M) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. 4 The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. 5 Oxypertine failed to antagonize the responses to potassium chloride. 6 These findings are compared with the effects of other antidepressant drugs.
采用大鼠离体输精管来检测精神安定抗焦虑药物奥昔哌汀的外周作用。
奥昔哌汀（4.4×10⁻¹⁰ M至2.6×10⁻⁵ M）竞争性拮抗去甲肾上腺素（pA₂ = 7.2）、5-羟色胺（pA₂ = 8.6）和多巴胺（pA₂ = 9.8）的作用。
奥昔哌汀（8.8×10⁻⁹ M至2.6×10⁻⁵ M）拮抗低浓度乙酰胆碱的作用，并增强高浓度乙酰胆碱引发的收缩。
奥昔哌汀可降低输精管经壁刺激所诱发的收缩。
奥昔哌汀未能拮抗对氯化钾的反应。
将这些发现与其他抗抑郁药物的作用进行了比较。
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