Lian Lian, Xia You-You, Zhou Chong, Shen Xiao-Ming, Li Xiang-Li, Han Shu-Guang, Zheng Yan, Mao Zhong-Qi, Gong Fei-Ran, Wu Meng-Yao, Chen Kai, Tao Min, Li Wei
Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu, China.
Cancer Biomark. 2015;15(6):899-907. doi: 10.3233/CBM-150534.
Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths worldwide. China has a high incidence of gastric cancer. Inflammation is a critical component of tumor progression. It has been widely accepted that gastric cancer is an inflammation-driven cancer. In this study, we investigated the application value of systemic inflammatory response (SIR) markers, platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR), in early diagnosis and prognostic prediction in patients with resectable gastric cancer.
One hundred and sixty-two patients with resectable gastric cancer were included and separated into groups according to median pre-operative PLR or NLR values (PLR low: < 208 or PLR high: ≥ 208, and NLR low: < 4.02 or NLR high: ≥ 4.02, respectively). To evaluate the changes in PLR or NLR values after operation, we introduced the concept of postpre-operative PLR or NLR ratios (< 1 indicated PLR or NLR values were decreased after operation, while ≥ 1 suggested not decreased PLR or NLR values).
Pre-operative PLR and NLR levels were significantly higher in gastric cancer patients compared with the healthy subjects. Low pre-operative PLR and NLR levels correlated with better clinicopathological features, including decreased depth of invasion, less lymph node metastasis and early tumor stage. Kaplan-Meier plots illustrated that higher pre-operative NLR and PLR had decreased overall survival (OS) and disease-free survival (DFS). Surgical tumor resection resulted in a significant
PLR and NLR measurements can provide important diagnostic and prognostic results in patients with resectable gastric cancer.
胃癌是全球第四大常见癌症，也是癌症相关死亡的第二大原因。中国胃癌发病率较高。炎症是肿瘤进展的关键组成部分。胃癌是一种炎症驱动型癌症已被广泛接受。在本研究中，我们调查了全身炎症反应（SIR）标志物、血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）在可切除胃癌患者早期诊断和预后预测中的应用价值。
纳入162例可切除胃癌患者，并根据术前PLR或NLR值的中位数分为几组（PLR低：<208或PLR高：≥208，NLR低：<4.02或NLR高：≥4.02）。为了评估术后PLR或NLR值的变化，我们引入了术前术后PLR或NLR比值的概念（<1表示术后PLR或NLR值降低，而≥1表示PLR或NLR值未降低）。
与健康受试者相比，胃癌患者术前PLR和NLR水平显著更高。术前PLR和NLR水平低与更好的临床病理特征相关，包括侵袭深度降低、淋巴结转移减少和肿瘤分期较早。Kaplan-Meier曲线表明，术前较高的NLR和PLR降低了总生存期（OS）和无病生存期（DFS）。手术切除肿瘤导致显著
PLR和NLR测量可为可切除胃癌患者提供重要的诊断和预后结果。
