Yagi Hideki, Sumino Hiroyuki, Aoki Tomoyuki, Tsunekawa Katsuhiko, Araki Osamu, Kimura Takao, Nara Makoto, Ogiwara Takayuki, Murakami Masami
Clin Hemorheol Microcirc. 2016;62(2):139-50. doi: 10.3233/CH-151960.
To investigate the relationship between blood rheology and endothelial function in patients with coronary risk factors, brachial arterial flow-mediated vasodilatation (FMD), an index of endothelial function and blood passage time (BPT), an index of blood rheology, and fasting blood cell count, glucose metabolism, and plasma fibrinogen, lipid, C-reactive protein, and whole blood viscosity levels were measured in 95 patients with coronary risk factors and 37 healthy controls. Brachial arterial FMD after reactive hyperemia was assessed by ultrasonography. BPT was assessed using the microchannel method. In healthy controls, BPT significantly correlated with FMD (r = - 0.325, p < 0.05), HDL cholesterol (r = - 0.393, p < 0.05), body mass index (BMI; r = 0.530, p < 0.01), and plasma fibrinogen concentration (r = 0.335, p < 0.05). In a multivariate regression analysis adjusted for all clinical variables, BPT remained significantly associated with BMI and fibrinogen, but not with FMD, in healthy controls. In patients with coronary risk factors, BPT significantly correlated with FMD (r = - 0.331, p < 0.01), HDL cholesterol (r = - 0.241, p < 0.05), BMI (r = 0.290, p < 0.01), hematocrit (r = 0.422, p < 0.001), white blood cell count (r = 0.295, p < 0.01), platelet count (r = 0.204, p < 0.05), and insulin (r = 0.210, p < 0.05). In a multivariate regression analysis adjusted for all clinical variables, BPT remained strongly associated with FMD and hematocrit in patients with coronary risk factors. These data indicate that BPT is closely associated with FMD in patients with coronary risk factors and suggest that the measurement of blood rheology using the microchannel method may be useful in evaluating brachial arterial endothelial function as a marker of atherosclerosis in these patients.
为研究具有冠心病危险因素患者的血液流变学与内皮功能之间的关系，对95例具有冠心病危险因素的患者和37例健康对照者测量了肱动脉血流介导的血管舒张功能（FMD，内皮功能指标）、血液通过时间（BPT，血液流变学指标）以及空腹血细胞计数、糖代谢、血浆纤维蛋白原、血脂、C反应蛋白和全血粘度水平。通过超声检查评估反应性充血后肱动脉的FMD。使用微通道法评估BPT。在健康对照者中，BPT与FMD（r = -0.325，p < 0.05）、高密度脂蛋白胆固醇（HDL胆固醇，r = -0.393，p < 0.05）、体重指数（BMI；r = 0.530，p < 0.01）和血浆纤维蛋白原浓度（r = 0.335，p < 0.05）显著相关。在对所有临床变量进行校正的多因素回归分析中，在健康对照者中，BPT仍与BMI和纤维蛋白原显著相关，但与FMD无关。在具有冠心病危险因素的患者中，BPT与FMD（r = -0.331，p < 0.01）、HDL胆固醇（r = -0.241，p < 0.05）、BMI（r = 0.290，p < 0.01）、血细胞比容（r = 0.422，p < 0.001）、白细胞计数（r = 0.295，p < 0.01）、血小板计数（r = 0.204，p < 0.05）和胰岛素（r = 0.210，p < 0.05）显著相关。在对所有临床变量进行校正的多因素回归分析中，在具有冠心病危险因素的患者中，BPT仍与FMD和血细胞比容密切相关。这些数据表明，在具有冠心病危险因素的患者中，BPT与FMD密切相关，并提示使用微通道法测量血液流变学可能有助于评估肱动脉内皮功能，作为这些患者动脉粥样硬化的一个标志物。
