肺炎克雷伯菌肝脓肿患者局部静脉血栓形成的影响
Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess.
作者信息
Molton James S, Chee Yen Lin, Hennedige Tiffany P, Venkatesh Sudhakar K, Archuleta Sophia
机构信息
University Medicine Cluster, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Hematology-Oncology, National University Health System, Singapore.
出版信息
PLoS One. 2015 Oct 7;10(10):e0140129. doi: 10.1371/journal.pone.0140129. eCollection 2015.
Klebsiella liver abscess (KLA) is an emerging infection in Asia caused by hypermucoviscous strains of Klebsiella pneumoniae. It is associated with thrombophlebitis of portal and hepatic veins. The natural history and role of anticoagulation for this regional thrombophlebitis is unclear. In a retrospective study of 169 subjects with KLA over 7 years, thrombophlebitis was identified in 53/169 (31.4%). Only 1 received therapeutic anticoagulation. Despite this 30/49 (73.2%) of those with follow up scan available showed improvement or recanalization (mean duration between scans 44 days). Abscess resolution was associated with improvement in thrombophlebitis.
肺炎克雷伯菌肝脓肿（KLA）是亚洲一种由肺炎克雷伯菌高黏液菌株引起的新发感染。它与门静脉和肝静脉血栓性静脉炎有关。这种局部血栓性静脉炎的自然病史及抗凝治疗的作用尚不清楚。在一项对169例KLA患者进行的为期7年的回顾性研究中，169例中有53例（31.4%）发现有血栓性静脉炎。只有1例接受了治疗性抗凝。尽管如此，在有后续扫描结果的49例患者中，有30例（73.2%）显示病情改善或血管再通（两次扫描之间的平均间隔时间为44天）。脓肿消退与血栓性静脉炎的改善相关。
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