Invasive Klebsiella pneumoniae Causing Concurrent Liver and Pulmonary Abscesses: Successful Management With Prolonged Oral Amoxicillin-Clavulanate.

We report a rare case of a 59-year-old male patient with poorly controlled diabetes mellitus who presented with concurrent hepatic and pulmonary abscesses. Imaging revealed a large septated hepatic lesion and multiple bilateral pulmonary cavities. Cultures from blood and drained hepatic pus confirmed . Despite the lack of genomic testing, the clinical course was consistent with invasive syndrome (IKPS). The patient was treated successfully with prolonged intravenous and oral amoxicillin-clavulanate over six months, along with percutaneous drainage of the hepatic abscess. Follow-up imaging demonstrated near-complete resolution of both liver and lung lesions. This case highlights the importance of early source control and extended culture-guided antibiotic therapy in managing severe invasive infections in immunocompromised patients.