Chen Iris, Clarke William, Ou San-San, Marzinke Mark A, Breaud Autumn, Emel Lynda M, Wang Jing, Hughes James P, Richardson Paul, Haley Danielle F, Lucas Jonathan, Rompalo Anne, Justman Jessica E, Hodder Sally L, Eshleman Susan H
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
PLoS One. 2015 Oct 7;10(10):e0140074. doi: 10.1371/journal.pone.0140074. eCollection 2015.
Antiretroviral (ARV) drug use was analyzed in HIV-uninfected women in an observational cohort study conducted in 10 urban and periurban communities in the United States with high rates of poverty and HIV infection. Plasma samples collected in 2009-2010 were tested for the presence of 16 ARV drugs. ARV drugs were detected in samples from 39 (2%) of 1,806 participants: 27/181 (15%) in Baltimore, MD and 12/179 (7%) in Bronx, NY. The ARV drugs detected included different combinations of non-nucleoside reverse transcriptase inhibitors and protease inhibitors (1-4 drugs/sample). These data were analyzed in the context of self-reported data on ARV drug use. None of the 39 women who had ARV drugs detected reported ARV drug use at any study visit. Further research is needed to evaluate ARV drug use by HIV-uninfected individuals.
在美国10个贫困率和艾滋病毒感染率较高的城市及城郊社区开展的一项观察性队列研究中，对未感染艾滋病毒的女性使用抗逆转录病毒（ARV）药物的情况进行了分析。对2009年至2010年采集的血浆样本检测了16种抗逆转录病毒药物。在1806名参与者中，有39人（2%）的样本检测出抗逆转录病毒药物：马里兰州巴尔的摩市为27/181（15%），纽约州布朗克斯区为12/179（7%）。检测出的抗逆转录病毒药物包括非核苷类逆转录酶抑制剂和蛋白酶抑制剂的不同组合（每个样本1 - 4种药物）。这些数据结合抗逆转录病毒药物使用的自我报告数据进行了分析。检测出抗逆转录病毒药物的39名女性在任何研究访视中均未报告使用过抗逆转录病毒药物。需要进一步研究以评估未感染艾滋病毒个体使用抗逆转录病毒药物的情况。
