一种有助于衣壳组装的油脂：来自一种嗜盐病毒的启示。

A Greasy Aid to Capsid Assembly: Lessons from a Salty Virus.

作者信息

Sankhala Rajeshwer S, Lokareddy Ravi K, Cingolani Gino

机构信息

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

出版信息

Structure. 2015 Oct 6;23(10):1777-1779. doi: 10.1016/j.str.2015.09.002.

DOI:10.1016/j.str.2015.09.002

PMID:26445488

Abstract

In this issue of Structure, Gil-Carton et al. (2015) use hybrid structural methods to investigate the architecture of the membrane-containing halovirus HHIV-2, a member of the PRD1-adenovirus lineage. This work sheds light on how lipid-proteins interactions guide the assembly of single β-barrel coat proteins to form an icosahedral capsid.

摘要

在本期《结构》杂志中，吉尔 - 卡尔顿等人（2015年）运用混合结构方法研究了含膜盐病毒HHIV - 2的结构，该病毒是PRD1 - 腺病毒谱系的成员。这项工作揭示了脂质 - 蛋白质相互作用如何引导单个β - 桶状衣壳蛋白组装形成二十面体衣壳。