从 FTO 基因座看 GWAS 数据的生物学意义。
Making Biological Sense of GWAS Data: Lessons from the FTO Locus.
机构信息
Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA.
Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA.
出版信息
Cell Metab. 2015 Oct 6;22(4):538-9. doi: 10.1016/j.cmet.2015.09.018.
GWAS have yielded many candidate loci for complex diseases like obesity, but interpreting the biological context of these findings has been difficult. Claussnitzer et al. (2015) use a sophisticated combination of bioinformatic and experimental approaches to address this bottleneck for variants in the FTO locus that associate with obesity.
GWAS 已经产生了许多与肥胖等复杂疾病相关的候选基因座，但解释这些发现的生物学背景一直很困难。Claussnitzer 等人（2015 年）使用生物信息学和实验方法的复杂组合，解决了与肥胖相关的 FTO 基因座变异的这一瓶颈问题。
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