Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cell Metab. 2015 Oct 6;22(4):543-5. doi: 10.1016/j.cmet.2015.09.020.
Tumors are metabolically heterogeneous, and subpopulations of tumorigenic cells have been recently described to rely more on mitochondrial respiration than glycolysis for energy production. In this issue, Sancho et al. (2015) demonstrate that MYC is a master switch regulating metabolic programs in different subpopulations of pancreatic tumor cells.
肿瘤在代谢上具有异质性，最近有研究描述了肿瘤发生细胞的亚群更依赖于线粒体呼吸而不是糖酵解来产生能量。在本期杂志中，Sancho 等人（2015）证明 MYC 是调节胰腺肿瘤细胞不同亚群代谢程序的主要开关。
