Chanchal Raj, Balasubramaniam Arumugam, Navin Raj, Nadeem Sayyed
Technocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), India.
Avicenna J Phytomed. 2015 Jul-Aug;5(4):282-7.
Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice.
Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus.
TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity.
The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior.
夹竹桃科植物鸡蛋花具有传统的民间药用功效，如抗癫痫、抗躁狂、补脑和抗氧化。本研究的目的是评估鸡蛋花叶乙醇提取物对小鼠埋珠行为的影响。
小鼠经口给予鸡蛋花乙醇提取物（100、200和300mg/kg）。氟西汀（FLX，一种选择性5-羟色胺再摄取抑制剂）用作对照药物。使用埋珠装置评估强迫行为。
100、200和300mg/kg剂量的鸡蛋花提取物剂量依赖性地抑制强迫行为。5、10和20mg/kg的氟西汀也得到了类似结果。鸡蛋花提取物和氟西汀均不影响运动活性。
结果表明，鸡蛋花提取物和氟西汀对埋珠行为产生类似的抑制作用。
