Vinué Ángela, González-Navarro Herminia
Institute of Health Research-INCLIVA, C/Menéndez Pelayo, 4, 46010, Valencia, Spain.
Methods Mol Biol. 2015;1339:247-54. doi: 10.1007/978-1-4939-2929-0_17.
In vivo metabolic tests are highly valuable to determine whether atherosclerosis progression in mouse models is accompanied by carbohydrate metabolism alterations such as glucose intolerance and insulin resistance. In this chapter, we describe protocols to perform in the mouse glucose and insulin tolerance tests, two metabolic assays which evaluate the glucose tolerance and the insulin sensitivity, respectively.
体内代谢测试对于确定小鼠模型中动脉粥样硬化进展是否伴有碳水化合物代谢改变（如葡萄糖不耐受和胰岛素抵抗）具有很高的价值。在本章中，我们描述了在小鼠中进行葡萄糖耐量试验和胰岛素耐量试验的方案，这两种代谢试验分别评估葡萄糖耐量和胰岛素敏感性。
