Basso Ricci S
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano.
Minerva Med. 1989 Jan;80(1):23-33.
The possibilities of medical treatment for the sequelae of radiotherapy of the various organs and apparatus are examined. Medical therapy may be utilised as a support in cases in which a favourable course is possible spontaneously, as a support in cases with chronic changes not liable to develop favourably, in cases with prospects of radical treatment, with substitutive purposes based therefore on the administration of substances that are missing as a result of the sequelae, as in the case of hormones after irradiation of endocrine organs, and finally for preventive purposes. The variously acting pharmacological substances applied locally or introduced generally which permit biological recovery, albeit partially, are recalled. The reversibility of certain sequelae, especially of those caused by the association with radiotherapy, must be borne in mind for adequate medical treatment. Medical treatment is hindered by the fact that many sequelae are caused by processes that are involved in the acute phase and which lead irreversible organic damage with few or no clinical signs. Nevertheless, when evolution is not yet complete, the anti-inflammatory substances, especially steroids, and anticoagulants of the heparin type, may prove to be very useful.
研究了针对各器官和组织放疗后遗症的医学治疗可能性。在有可能自发出现良好病程的情况下，医学治疗可用作一种支持手段；在慢性变化不太可能向好发展的情况下，医学治疗也可用作支持；在有根治性治疗前景的情况下，医学治疗还可用于替代目的，即基于补充因后遗症而缺乏的物质，比如内分泌器官受照射后补充激素；最后，医学治疗还可用于预防目的。回顾了局部应用或全身使用的各种具有不同作用的药理物质，这些物质尽管只能部分地促使生物恢复。在进行充分的医学治疗时，必须考虑到某些后遗症，特别是那些与放疗相关的后遗症的可逆性。医学治疗受到诸多阻碍，原因在于许多后遗症是由急性期所涉及的过程引起的，这些过程会导致不可逆转的器质性损害，且临床症状很少或没有。然而，当病情尚未完全发展时，抗炎物质，尤其是类固醇，以及肝素类抗凝剂可能会被证明非常有用。
