Plaza J A, Ballestín C, Pérez-Barrios A, Martínez M A, de Agustín P
Pathologic Anatomy Service, Gómez Ulla Military Hospital, Madrid, Spain.
Acta Cytol. 1989 Jan-Feb;33(1):89-92.
The cytologic, cytochemical, immunocytochemical and ultrastructural findings on the aspirated material are presented for the case of a 57-year-old man with sacrococcygeal chordoma diagnosed by fine needle aspiration biopsy. Cytologically, two types of cellular elements were differentiated: medium-sized cells with few cytoplasmic vacuoles and classic physaliferous cells. Both types showed marked cytoplasmic positivity for keratin and S-100 protein; the absence of nuclear positivity in the physaliferous cells was notable. Ultrastructural study demonstrated the existence of true intracytoplasmic vacuoles and frequent rough endoplasmic reticulum-mitochondria complexes. The cytologic differential diagnosis with chondrosarcoma, myxoid liposarcoma, ependymoma and metastases of mucosecretory carcinomas is reviewed.
本文呈现了一例经细针穿刺活检确诊为骶尾部脊索瘤的57岁男性患者吸出物的细胞学、细胞化学、免疫细胞化学及超微结构检查结果。细胞学上，可区分出两种细胞成分：胞质空泡较少的中等大小细胞和典型的泡状细胞。两种细胞类型的角蛋白和S-100蛋白在胞质中均呈显著阳性；泡状细胞中核呈阴性这一点值得注意。超微结构研究显示存在真正的胞质内空泡以及频繁的粗面内质网-线粒体复合体。文中还回顾了与软骨肉瘤、黏液样脂肪肉瘤、室管膜瘤及黏液分泌性癌转移灶的细胞学鉴别诊断。
