Jiang Bei-Ge, Yang Yuan, Liu Hui, Gu Fang-Ming, Yang Yun, Zhao Lin-Hao, Yuan Sheng-Xian, Wang Ruo-Yu, Zhang Jin, Zhou Wei-Ping
From the Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China (B-GJ, YY, HL, F-MG, YY, L-HZ, S-XY, R-YW, JZ, W-PZ).
Medicine (Baltimore). 2015 Oct;94(40):e1344. doi: 10.1097/MD.0000000000001344.
Previous studies showed that suppressor of cytokine signaling 3 (SOCS3) protein is associated with incidence and progression of hepatocellular carcinoma (HCC); however, the association between the genetic polymorphism of SOCS3 gene and HCC remains unknown. A total of 254 HCC patients and 354 healthy controls were enrolled. All HCC patients underwent partial hepatectomy as initial treatment and were followed. Three SOCS3 gene polymorphisms, namely, rs4969170 A>G, rs8064821 C>T, and rs12953258 C>A were determined. Our data show that the rs4969170 A>G polymorphism dramatically affects the susceptibility to HCC in our cohorts. Logistic regression analyses revealed that the rs4969170 GG is a risk factor for HCC after the adjustment with confounding factors. The rs4969170A>G polymorphism is also associated with the clinical features of HCC patients and predicts the postoperative relapse-free survival and overall survival. The rs4969170GG genotype carrier had a worse prognosis than the rs4969170AG and rs4969170AA carrier. Our findings suggest that the rs4969170A>G polymorphism of SOCS3 gene may be used as a prognostic predictor for HCC patients who underwent surgical treatment.
先前的研究表明，细胞因子信号转导抑制因子3（SOCS3）蛋白与肝细胞癌（HCC）的发生和进展相关；然而，SOCS3基因的基因多态性与HCC之间的关联仍不清楚。共纳入了254例HCC患者和354例健康对照。所有HCC患者均接受了部分肝切除术作为初始治疗并进行随访。测定了三个SOCS3基因多态性，即rs4969170 A>G、rs8064821 C>T和rs12953258 C>A。我们的数据表明，rs4969170 A>G多态性显著影响我们队列中HCC的易感性。逻辑回归分析显示，在校正混杂因素后，rs4969170 GG是HCC的一个危险因素。rs4969170A>G多态性也与HCC患者的临床特征相关，并可预测术后无复发生存期和总生存期。rs4969170GG基因型携带者的预后比rs4969170AG和rs4969170AA携带者更差。我们的研究结果表明，SOCS3基因的rs4969170A>G多态性可作为接受手术治疗的HCC患者的预后预测指标。
