Mulholland M W, Debas H T
Department of Surgery, University of Washington, Seattle.
Am J Surg. 1989 Feb;157(2):225-9. doi: 10.1016/0002-9610(89)90533-3.
Transmural proximal gastric vagotomy, an experimental procedure designed to denervate the gastric fundus by intramural division of vagal fibers, was evaluated as a means of reducing stimulated gastric acid output. The procedure reduced peak acid output in response to insulin stimulation by 71 percent. Acid production was not further decreased by extramural division of vagal fibers. It also decreased parietal cell sensitivity to pentagastrin stimulation and did not interfere with emptying of a liquid meal. We have concluded that transmural proximal gastric vagotomy is technically straightforward, reliably divides fundic vagal fibers, produces a significant reduction in acid production equivalent to that produced by standard operative techniques, and does not interfere with gastric emptying.
经壁近端胃迷走神经切断术是一种通过壁内切断迷走神经纤维来使胃底去神经支配的实验性手术，该手术被评估为一种降低刺激胃酸分泌量的方法。该手术使胰岛素刺激后的胃酸分泌峰值降低了71%。迷走神经纤维的壁外切断并未使胃酸分泌进一步减少。它还降低了壁细胞对五肽胃泌素刺激的敏感性，并且不干扰流食的排空。我们得出结论，经壁近端胃迷走神经切断术在技术上简单直接，能可靠地切断胃底迷走神经纤维，使胃酸分泌量显著降低，与标准手术技术产生的效果相当，并且不干扰胃排空。
