Bittencourt Marcio Sommer, Cerci Rodrigo Julio
Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute; University of São Paulo School of Medicine, Av. Lineu Prestes, 2565, São Paulo, 05508-000, Brazil.
Preventive Medicine Center, Hospital Israelita Albert Einstein, São Paulo, Brazil.
BMC Med. 2015 Oct 8;13:260. doi: 10.1186/s12916-015-0499-9.
Despite the well-documented improved survival of coronary heart disease with the use of statins, their effects on atherosclerotic plaques are not yet fully understood. While some studies suggest statins may reduce plaque volume, the reduction is small even with the use of high-dose statins. Due to this small change in plaque volume, other effects of statin therapy on plaques have been proposed. A large meta-analysis by Banach et al. explored statin effects on plaque composition detected by intravascular ultrasound (IVUS). We discuss the mechanisms of plaque composition modification demonstrated in their study and its implications on atherosclerotic plaque stabilization. Please see related article: http://www.biomedcentral.com/1741-7015/13/229.
尽管有充分的文献证明使用他汀类药物可改善冠心病患者的生存率,但其对动脉粥样硬化斑块的影响尚未完全明确。虽然一些研究表明他汀类药物可能会减小斑块体积,但即使使用高剂量他汀类药物,这种减小幅度也很小。由于斑块体积变化不大,因此有人提出了他汀类药物治疗对斑块的其他影响。Banach等人进行的一项大型荟萃分析探讨了他汀类药物对血管内超声(IVUS)检测到的斑块成分的影响。我们将讨论他们研究中所证明的斑块成分改变机制及其对动脉粥样硬化斑块稳定的意义。请参阅相关文章:http://www.biomedcentral.com/1741-7015/13/229 。