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农药及其作为农用化学品的用途。

Propesticides and their use as agrochemicals.

作者信息

Jeschke Peter

机构信息

Bayer CropScience AG, Monheim am Rhein, Germany.

出版信息

Pest Manag Sci. 2016 Feb;72(2):210-25. doi: 10.1002/ps.4170. Epub 2015 Nov 27.

Abstract

The synthesis of propesticides is an important concept in design of modern agrochemicals with optimal efficacy, environmental safety, user friendliness and economic variability. Based on increasing knowledge of the biochemistry and genetics of major pest insects, weeds and agricultural pathogens, the search for selectivity has become an ever more important part of pesticide development and can be achieved by appropriate structural modifications of the active ingredient. Propesticides affect the absorption, distribution, metabolism and excretion parameters, which can lead to biological superiority of these modified active ingredients over their non-derivatised analogues. Various selected commercial propesticides testify to the successful utilisation of this concept in the design of agrochemicals. This review describes comprehensively the successful utilisation of propesticides and their role in syntheses of modern agrochemicals, exemplified by selected commercial products coming from different agrochemical areas.

摘要

前体农药的合成是现代农用化学品设计中的一个重要概念,这些农用化学品需具备最佳药效、环境安全性、用户友好性和经济可行性。基于对主要害虫、杂草及农业病原体生物化学和遗传学知识的不断增加,寻找选择性已成为农药开发中日益重要的一部分,并且可以通过对活性成分进行适当的结构修饰来实现。前体农药会影响吸收、分布、代谢和排泄参数,这可能使这些经过修饰的活性成分相较于其未衍生化的类似物具有生物学优势。各种选定的商用前体农药证明了这一概念在农用化学品设计中的成功应用。本综述全面描述了前体农药的成功应用及其在现代农用化学品合成中的作用,并以来自不同农用化学品领域的选定商业产品为例进行说明。

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