非溶血性和无色素B族链球菌，早发型新生儿败血症的罕见病因。

Non-haemolytic and non-pigmented group b streptococcus, an infrequent cause of early onset neonatal sepsis.

作者信息

Rodriguez-Granger Javier, Spellerberg Barbara, Asam Daniela, Rosa-Fraile Manuel

机构信息

University Hospital Virgen de las Nieves, Microbiology, Granada, 18014 Spain.

University Hospital of Ulm, Institute of Medical Microbiology and Hospital Hygiene, Ulm, 89081 Germany.

出版信息

Pathog Dis. 2015 Dec;73(9):ftv089. doi: 10.1093/femspd/ftv089. Epub 2015 Oct 7.

DOI:10.1093/femspd/ftv089

PMID:26449711

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4626576/

Abstract

The haemolysin of Group B streptococci (GBS), a leading cause of neonatal infections, is a key virulence factor that has been implicated in the development of invasive infection. The frequency of non-haemolytic (NH) GBS isolates is around 5% among GBS carriers. To determine if similar rates are observed among invasive strains, we evaluated the incidence of NH strains among 199 GBS strains isolated from neonatal blood cultures (first week of life). Overall, we found two (1%) NH strains. This finding suggests that the frequency of NH GBS strains causing early onset invasive neonatal infection is lower than the reported frequency of NH GBS among colonizing strains.

摘要

B族链球菌（GBS）的溶血素是新生儿感染的主要原因，是一种关键的毒力因子，与侵袭性感染的发生有关。在GBS携带者中，非溶血（NH）GBS分离株的频率约为5%。为了确定侵袭性菌株中是否观察到类似的比例，我们评估了从新生儿血培养（出生后第一周）分离出的199株GBS菌株中NH菌株的发生率。总体而言，我们发现了两株（1%）NH菌株。这一发现表明，引起早发性侵袭性新生儿感染的NH GBS菌株的频率低于报道的定植菌株中NH GBS的频率。