半乳糖凝集素-3作为上皮连接的调节因子：对伤口修复和癌症的影响。
Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer.
作者信息
Argüeso Pablo, Mauris Jerome, Uchino Yuichi
机构信息
Schepens Eye Research Institute and Massachusetts Eye and Ear; Department of Ophthalmology ; Harvard Medical School; Boston, MA USA.
出版信息
Tissue Barriers. 2015 Mar 17;3(3):e1026505. doi: 10.1080/21688370.2015.1026505. eCollection 2015 Jul-Sep.
Abstract
Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.
摘要
上皮细胞通过一组黏附连接彼此紧密相连，并与细胞外基质相连，这些黏附连接赋予组织独特的屏障特性，并在细胞形态、组织生理学和细胞信号传导中发挥重要作用。本综述重点介绍了在理解半乳糖凝集素-3（一种对β-半乳糖苷具有亲和力的碳水化合物结合蛋白）作为上皮连接组装和功能调节剂方面所取得的进展。讨论了半乳糖凝集素-3在黏附结构中的相互作用与伤口愈合和肿瘤进展的关系。
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