Liu Wenqi, Peck Evan M, Hendzel Kevin D, Smith Bradley D
Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame , Notre Dame, Indiana 46556, United States.
Org Lett. 2015 Nov 6;17(21):5268-71. doi: 10.1021/acs.orglett.5b02633. Epub 2015 Oct 9.
A macrocyclic tetralactam is threaded by a complementary squaraine dye that is flanked by two polyethylene glycol chains to produce a pseudorotaxane complex with favorable near-infrared fluorescence properties. The association thermodynamics and kinetics were measured for a homologous series of squaraines with different N-alkyl substituents at both ends of the dye. The results show that subtle changes in substituent steric size have profound effects on threading kinetics without greatly altering the very high association constant.
一种大环四内酰胺被一种互补的方酸菁染料贯穿,该染料两侧连接有两条聚乙二醇链,从而产生具有良好近红外荧光特性的准轮烷复合物。对一系列在染料两端具有不同N-烷基取代基的方酸菁同系物的缔合热力学和动力学进行了测定。结果表明,取代基空间尺寸的细微变化对贯穿动力学有深远影响,而不会显著改变非常高的缔合常数。