NB001对关节痛小鼠模型的镇痛作用。
Analgesic effects of NB001 on mouse models of arthralgia.
作者信息
Tian Zhen, Wang Dong-sheng, Wang Xin-shang, Tian Jiao, Han Jing, Guo Yan-yan, Feng Bin, Zhang Nan, Zhao Ming-gao, Liu Shui-bing
机构信息
Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, China.
Department of Orthopedics, Jinling Hospital, Clinical School of Nanjing, Second Military Medical University, Nanjing, 210002, China.
出版信息
Mol Brain. 2015 Oct 9;8(1):60. doi: 10.1186/s13041-015-0151-9.
Our previous studies have demonstrated the critical roles of calcium-stimulated adenylyl cyclase 1 (AC1) in the central nervous system in chronic pain. In the present study, we examined the analgesic effects of NB001, a selective inhibitor of AC1, on animal models of ankle joint arthritis and knee joint arthritis induced by complete Freund's adjuvant injection. NB001 treatment had no effect on joint edema, stiffness, and joint destruction. Furthermore, the treatment failed to attenuate the disease progression of arthritis. However, NB001 treatment (3 mg/kg) significantly weakened joint pain-related behavior in the mouse models of ankle joint arthritis and knee joint arthritis. Results indicated that NB001 exhibited an analgesic effect on the animal models of arthritis but was not caused by anti-inflammatory activities.
我们之前的研究已经证明钙刺激的腺苷酸环化酶1（AC1）在慢性疼痛的中枢神经系统中起关键作用。在本研究中，我们研究了AC1的选择性抑制剂NB001对完全弗氏佐剂注射诱导的踝关节关节炎和膝关节关节炎动物模型的镇痛作用。NB001治疗对关节水肿、僵硬和关节破坏没有影响。此外，该治疗未能减缓关节炎的疾病进展。然而，NB001治疗（3mg/kg）显著减弱了踝关节关节炎和膝关节关节炎小鼠模型中与关节疼痛相关的行为。结果表明，NB001对关节炎动物模型具有镇痛作用，但并非由抗炎活性引起。
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