Willson J K
Ireland Cancer Center, University Hospitals of Cleveland, Ohio.
Hematol Oncol Clin North Am. 1989 Mar;3(1):19-34.
The progression of large bowel cancer from the colon crypt cell involves a series of sequential stages of altered growth regulation. An increase in the proliferative compartment of the colonic crypt characterizes the earliest stage. This is followed by loss of normal maturation and gain of more autonomous growth. Ultimately, cells that acquire the capability to migrate and grow at a distant site appear as metastases. Clinical and pathologic observations have been used to identify these stages of large bowel cancer progression, but only with the recent application of molecular and biologic tools are we beginning to identify potential mechanisms responsible for the altered growth. The development of laboratory models that reflect the key clinical and pathologic stages of progression should prove particularly valuable in sorting out the biology of large bowel tumor progression. The challenge then will be to use this knowledge for the design of preventive and therapeutic strategies.
从结肠隐窝细胞发展而来的大肠癌涉及一系列生长调节改变的连续阶段。结肠隐窝增殖区的增加是最早阶段的特征。随后是正常成熟的丧失和更自主生长的获得。最终，获得在远处迁移和生长能力的细胞会出现转移。临床和病理观察已被用于识别大肠癌进展的这些阶段，但直到最近应用分子和生物学工具，我们才开始确定导致生长改变的潜在机制。开发反映进展关键临床和病理阶段的实验室模型在梳理大肠肿瘤进展生物学方面应会特别有价值。接下来的挑战将是利用这些知识来设计预防和治疗策略。
