免疫-交感神经系统相互作用在高血压发生发展中的相关性。

Relevance of Immune-Sympathetic Nervous System Interplay for the Development of Hypertension.

作者信息

Winklewski Pawel J, Radkowski Marek, Demkow Urszula

出版信息

Adv Exp Med Biol. 2016;884:37-43. doi: 10.1007/5584_2015_169.

DOI:10.1007/5584_2015_169

Abstract

Historically, the sympathetic nervous system (SNS) has been mostly associated with the 'fight or flight' response and the regulation of cardiovascular function. However, evidence over the past 30 years suggests that SNS may also influence the function of immune cells. In this review we describe the basic research being done in the area of SNS regulation of immune function. Further, we show that the SNS-immune interplay during circadian rhythm may modulate the robustness of the inflammatory response, critical for survival during periods of increased activity. Finally, new concepts of a close relationship between these systems in the pathogenesis of hypertension are discussed.

摘要

从历史上看，交感神经系统（SNS）主要与“战斗或逃跑”反应以及心血管功能调节相关。然而，过去30年的证据表明，SNS也可能影响免疫细胞的功能。在本综述中，我们描述了在SNS调节免疫功能领域所开展的基础研究。此外，我们表明，昼夜节律期间SNS与免疫的相互作用可能会调节炎症反应的强度，这对活动增加期间的生存至关重要。最后，还讨论了这些系统在高血压发病机制中密切关系的新概念。