Postgraduate Program in Health Sciences, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
J Microbiol Immunol Infect. 2016 Dec;49(6):980-983. doi: 10.1016/j.jmii.2015.08.025. Epub 2015 Sep 21.
We report the in vitro drugs interaction by the resazurin drugs combination microtiter assay (REDCA) of amoxicillin (AMO)/clavulanate (CLAV) with isoniazid (INH), ethambutol (EMB), and rifampicin (RIF) against susceptible and resistant Mycobacterium tuberculosis isolates. The addition of AMO/CLAV to classical antituberculosis drugs should be explored as a promising alternative for the treatment of resistant tuberculosis (TB).
我们报告了通过 Resazurin 药物组合微量滴定测定法（REDCA）进行的阿莫西林（AMO）/克拉维酸（CLAV）与异烟肼（INH）、乙胺丁醇（EMB）和利福平（RIF）的体外药物相互作用，以对抗敏感和耐药结核分枝杆菌分离株。在治疗耐药结核病（TB）方面，应探索添加 AMO/CLAV 作为经典抗结核药物的一种有前途的替代方案。
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