Xia Bo, Tan Meiyun
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015 Jan;29(1):103-7.
To comprehensively analyze and compare the biological difference between bone marrow mesenchymal stem cells (BMSCs) and placenta-derived MSCs (PMSCs) in hypoxia and to extend the knowledge for seed cells selection.
The domestic and foreign related literature about the effects of hypoxia microenvironment on proliferation, apoptosis, differentiation, paracrine secretion, migration, and homing ability of BMSCs and PMSCs were summarized and analysed.
PMSCs proliferated much faster and more sensitive to the hypoxia than BMSCs; in addition, PMSCs showed stronger survivability. Similar to BMSCs, PMSCs can home to hypoxic-ischemic tissues efficiently, secrete a lot of growth factors and differentiate into tissue-specific cells to stimulate tissue regeneration.
PMSCs as the seed cells will have broad application prospects in the regenerative medicine.
全面分析和比较骨髓间充质干细胞（BMSCs）与胎盘来源的间充质干细胞（PMSCs）在缺氧状态下的生物学差异，为种子细胞的选择提供更多依据。
总结并分析国内外关于缺氧微环境对BMSCs和PMSCs增殖、凋亡、分化、旁分泌、迁移及归巢能力影响的相关文献。
PMSCs比BMSCs增殖更快且对缺氧更敏感；此外，PMSCs具有更强的生存能力。与BMSCs类似，PMSCs能够有效归巢至缺氧缺血组织，分泌大量生长因子并分化为组织特异性细胞以刺激组织再生。
PMSCs作为种子细胞在再生医学中将具有广阔的应用前景。
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