Hart Melanie L, Kaupp Marvin, Brun Juliane, Aicher Wilhelm K
University of Freiburg, Department of Orthopedics and Trauma Surgery, Germany; Clinical Research Group KFO 273, Department of Urology, University of Tübingen, Germany.
Clinical Research Group KFO 273, Department of Urology, University of Tübingen, Germany.
Placenta. 2017 Jan;49:64-67. doi: 10.1016/j.placenta.2016.11.007. Epub 2016 Nov 16.
Placenta-derived mesenchymal stromal cells (pMSCs) are a very attractive source of MSCs. In this short report we evaluated the expression of phenotypic markers from fetal and maternal pMSCs after exposure to myogenic medium commonly used to differentiate bone marrow MSCs (bmMSCs) to smooth muscle-like cells (SMCs). In order to reveal differences between these different MSC sources, cells were expanded and differentiated to elucidate whether this differentiation protocol facilitated efficient differentiation of SMCs from human pMSCs. We report that TGF-β1, PDGF and ascorbic acid is not sufficient to produce SMCs from pMSCs.
胎盘来源的间充质基质细胞（pMSCs）是一种非常有吸引力的间充质干细胞来源。在本简短报告中，我们评估了胎儿和母体pMSCs在暴露于常用于将骨髓间充质干细胞（bmMSCs）分化为平滑肌样细胞（SMCs）的成肌培养基后，其表型标志物的表达。为了揭示这些不同间充质干细胞来源之间的差异，对细胞进行了扩增和分化，以阐明该分化方案是否有助于从人pMSCs高效分化出SMCs。我们报告称，转化生长因子-β1（TGF-β1）、血小板衍生生长因子（PDGF）和抗坏血酸不足以从pMSCs产生SMCs。
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