使用推拉式二甲基氨基噻吩衍生物对β-淀粉样蛋白斑块进行体内荧光成像。
In vivo fluorescence imaging of β-amyloid plaques with push-pull dimethylaminothiophene derivatives.
作者信息
Watanabe Hiroyuki, Ono Masahiro, Saji Hideo
机构信息
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
出版信息
Chem Commun (Camb). 2015 Dec 14;51(96):17124-7. doi: 10.1039/c5cc06628j.
In vivo fluorescence imaging of β-amyloid (Aβ) plaques in the brain is expected to be used as a new method for detecting Alzheimer's disease (AD). We synthesized novel push-pull dimethylaminothiophenyl (DTM) derivatives and evaluated their utility as in vivo fluorescence imaging probes targeting Aβ plaques. As a result, we found that DTM-2 is a promising fluorescent probe for Aβ plaques in the AD brains.
大脑中β-淀粉样蛋白（Aβ）斑块的体内荧光成像有望用作检测阿尔茨海默病（AD）的新方法。我们合成了新型推拉式二甲基氨基硫苯基（DTM）衍生物，并评估了它们作为靶向Aβ斑块的体内荧光成像探针的效用。结果，我们发现DTM-2是用于AD大脑中Aβ斑块的一种有前景的荧光探针。
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