老年女性的抗阻训练与白质病变进展：一项12个月随机对照试验的探索性分析
Resistance Training and White Matter Lesion Progression in Older Women: Exploratory Analysis of a 12-Month Randomized Controlled Trial.
作者信息
Bolandzadeh Niousha, Tam Roger, Handy Todd C, Nagamatsu Lindsay S, Hsu Chun Liang, Davis Jennifer C, Dao Elizabeth, Beattie B Lynn, Liu-Ambrose Teresa
机构信息
Aging, Mobility and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, British Columbia, Canada.
Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
J Am Geriatr Soc. 2015 Oct;63(10):2052-60. doi: 10.1111/jgs.13644. Epub 2015 Oct 12.
OBJECTIVES
To assess whether resistance training (RT) slows the progression of white matter lesions (WMLs) in older women.
DESIGN
Secondary analysis of a 52-week randomized controlled trial of RT, the Brain Power Study.
SETTING
Community center and research center.
PARTICIPANTS
Of 155 community-dwelling women aged 65 to 75 enrolled in the Brain Power Study, 54 who had evidence of WMLs on magnetic resonance imaging (MRI) at baseline were included in this secondary analysis.
INTERVENTION
Participants were randomized to once-weekly RT (1× RT), twice-weekly RT (2× RT), or twice-weekly balance and tone (BAT). Assessors were blinded to participant assignments.
MEASUREMENTS
WML volume was measured using MRI at baseline and trial completion.
RESULTS
At trial completion, the 2× RT group had significantly lower WML volume than the BAT group (P = .03). There was no significant difference between the BAT group and the 1× RT group at trial completion (P = .77). Among participants in the two RT groups, reduced WML progression over 12 months was significantly associated with maintenance of gait speed (correlation coefficient (r) = -0.31, P = .049) but not with executive functions (r = 0.30; P = .06).
CONCLUSION
Engaging in progressive RT may reduce WML progression.
目的
评估抗阻训练（RT）是否能减缓老年女性白质病变（WMLs）的进展。
设计
对一项为期52周的抗阻训练随机对照试验（脑动力研究）进行二次分析。
设置
社区中心和研究中心。
参与者
在脑动力研究中登记的155名年龄在65至75岁的社区居住女性中，54名在基线磁共振成像（MRI）时有WMLs证据的女性被纳入该二次分析。
干预
参与者被随机分为每周一次抗阻训练（1×RT）、每周两次抗阻训练（2×RT）或每周两次平衡与韵律训练（BAT）。评估者对参与者的分组不知情。
测量
在基线和试验结束时使用MRI测量WML体积。
结果
在试验结束时，2×RT组的WML体积显著低于BAT组（P = 0.03）。试验结束时，BAT组和1×RT组之间无显著差异（P = 0.77）。在两个抗阻训练组的参与者中，12个月内WML进展的减缓与步态速度的维持显著相关（相关系数（r）= -0.31，P = 0.049），但与执行功能无关（r = 0.30；P = 0.06）。
结论
进行渐进性抗阻训练可能会减少WML的进展。
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