Liu-Ambrose Teresa, Nagamatsu Lindsay S, Graf Peter, Beattie B Lynn, Ashe Maureen C, Handy Todd C
BrainResearch Centre, Centre for Hip Health and Mobility, Vancouver Coastal Research Institute, Department of Physical Therapy, University of British Columbia. 357-2647 Willow St, Vancouver, BC V5Z 3P1, Canada.
Arch Intern Med. 2010 Jan 25;170(2):170-8. doi: 10.1001/archinternmed.2009.494.
Cognitive decline among seniors is a pressing health care issue. Specific exercise training may combat cognitive decline. We compared the effect of once-weekly and twice-weekly resistance training with that of twice-weekly balance and tone exercise training on the performance of executive cognitive functions in senior women.
In this single-blinded randomized trial, 155 community-dwelling women aged 65 to 75 years living in Vancouver were randomly allocated to once-weekly (n = 54) or twice-weekly (n = 52) resistance training or twice-weekly balance and tone training (control group) (n = 49). The primary outcome measure was performance on the Stroop test, an executive cognitive test of selective attention and conflict resolution. Secondary outcomes of executive cognitive functions included set shifting as measured by the Trail Making Tests (parts A and B) and working memory as assessed by verbal digit span forward and backward tests. Gait speed, muscular function, and whole-brain volume were also secondary outcome measures.
Both resistance training groups significantly improved their performance on the Stroop test compared with those in the balance and tone group (P < or = .03). Task performance improved by 12.6% and 10.9% in the once-weekly and twice-weekly resistance training groups, respectively; it deteriorated by 0.5% in the balance and tone group. Enhanced selective attention and conflict resolution was significantly associated with increased gait speed. Both resistance training groups demonstrated reductions in whole-brain volume compared with the balance and tone group at the end of the study (P < or = .03).
Twelve months of once-weekly or twice-weekly resistance training benefited the executive cognitive function of selective attention and conflict resolution among senior women.
clinicaltrials.gov Identifier: NCT00426881.
老年人认知功能下降是一个紧迫的医疗保健问题。特定的运动训练可能有助于对抗认知功能下降。我们比较了每周一次和每周两次的阻力训练与每周两次的平衡和肌肉张力训练对老年女性执行认知功能表现的影响。
在这项单盲随机试验中，155名年龄在65至75岁之间、居住在温哥华的社区女性被随机分配到每周一次（n = 54）或每周两次（n = 52）的阻力训练组，或每周两次的平衡和肌肉张力训练组（对照组）（n = 49）。主要结局指标是Stroop测试的表现，这是一项用于评估选择性注意力和冲突解决能力的执行认知测试。执行认知功能的次要结局指标包括通过连线测验（A和B部分）测量的任务转换能力，以及通过言语数字广度顺背和倒背测试评估的工作记忆。步速、肌肉功能和全脑体积也是次要结局指标。
与平衡和肌肉张力训练组相比，两个阻力训练组在Stroop测试中的表现均有显著改善（P≤0.03）。每周一次和每周两次的阻力训练组的任务表现分别提高了12.6%和10.9%；而平衡和肌肉张力训练组的任务表现下降了0.5%。选择性注意力和冲突解决能力的增强与步速加快显著相关。在研究结束时，与平衡和肌肉张力训练组相比，两个阻力训练组的全脑体积均有所减少（P≤0.03）。
为期12个月的每周一次或每周两次的阻力训练对老年女性选择性注意力和冲突解决方面的执行认知功能有益。
clinicaltrials.gov标识符：NCT00426881。
