Greenhawt Matthew
Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Lobby H-2100, Box 442, Ann Arbor, MI 48106, USA; Child Health Evaluation and Research Unit, Department of Pediatrics, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Lobby H-2100, Box 442, Ann Arbor, MI 48106, USA.
Pediatr Clin North Am. 2015 Dec;62(6):1509-21. doi: 10.1016/j.pcl.2015.07.010.
Observational studies have explored associations between timing of peanut, egg, and milk introduction and food allergy development, noting significant associations with reduced respective rates of milk, egg, and peanut allergy associated with earlier timing of introduction. Interventional studies developed to more definitively explore these outcomes have been published for egg and peanut, and are ongoing for multiple other allergens. This review focuses on the recent publication regarding the LEAP (Learning Early About Peanut Allergy) study, its highly favorable results, the policy implications of its findings, and the horizon for primary prevention as a realistic strategy to prevent food allergy.
观察性研究探讨了引入花生、鸡蛋和牛奶的时间与食物过敏发展之间的关联,指出引入时间越早,牛奶、鸡蛋和花生过敏的发生率分别显著降低。为更明确地探究这些结果而开展的干预性研究中,关于鸡蛋和花生的研究已发表,针对多种其他过敏原的研究正在进行。本综述重点关注近期发表的关于LEAP(早期了解花生过敏)研究、其极为有利的结果、研究结果的政策影响以及作为预防食物过敏的现实策略的一级预防前景。