口腔免疫治疗中的生物标志物。
Biomarkers in oral immunotherapy.
机构信息
Department of Pediatrics (No. 3 Ward), Northwest Women's and Children's Hospital, Xi'an 710061, China.
Department of Urology, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
出版信息
J Zhejiang Univ Sci B. 2022;23(9):705-731. doi: 10.1631/jzus.B2200047.
Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT. Several immunological indicators have been used as biomarkers in OIT, such as skin prick tests, basophil and mast cell reactivity, T cell and B cell responses, allergen-specific antibody levels, and cytokines. Other novel indicators also could be potential biomarkers. In this review, we discuss and assess the application of various immunological indicators as biomarkers for OIT.
食物过敏（FA）是一个全球性的健康问题，影响着大量人群，因此，人们非常希望找到有效的治疗方法。口服免疫疗法（OIT）在大多数 FA 患者中显示出了合理的疗效和良好的安全性。在 OIT 期间，需要可靠的生物标志物来评估治疗效果和预测结果。已经有几种免疫指标被用作 OIT 的生物标志物，如皮肤点刺试验、嗜碱性粒细胞和肥大细胞反应性、T 细胞和 B 细胞反应、过敏原特异性抗体水平和细胞因子等。其他新的指标也可能是潜在的生物标志物。在这篇综述中，我们讨论并评估了各种免疫指标作为 OIT 生物标志物的应用。
Zotero 插件