Vardar Enver, Yardim Bengü Günay, Vardar Rukiye, Ölmez Mustafa
Department of Pathology, Bozyaka İzmir Training and Research Hospital, İZMİR, TURKEY.
Turk Patoloji Derg. 2015;31(3):219-22. doi: 10.5146/tjpath.2014.01246.
Invasive micropapillary carcinoma is a recently identified neoplasm. A 77-year-old-female was admitted to the hospital due to progressive loss of weight and nausea. Endoscopic biopsy of the antral/prepyloric located mass was diagnosed as moderately differentiated adenocarcinoma. Subtotal gastrectomy and regional lymph node resection were performed. The tumor was composed of moderately differentiated cells arranged in micropapillary structures with only a few poorly formed glandular foci in lamina propria. Immunohistochemically, neoplastic cells of micropapillary and focal conventional adenocarcinoma areas were diffusely positive for pancytokeratin, cytokeratin 7 and epithelial membrane antigen. In micropapillary areas, membranous and peripheral cytoplasmic positivity with epithelial membrane antigen in outside of the cell clusters called "inside-out polarity" pattern that is characteristic for invasive micropapillary carcinoma were seen. Invasive micropapillary carcinoma is very rare in the stomach in the English literature.
浸润性微乳头状癌是一种最近才被确认的肿瘤。一名77岁女性因体重逐渐减轻和恶心入院。对位于胃窦/幽门前的肿块进行内镜活检，诊断为中分化腺癌。实施了胃次全切除术和区域淋巴结切除术。肿瘤由排列成微乳头结构的中分化细胞组成，固有层仅有少数形成不良的腺管灶。免疫组化显示，微乳头区域和局灶性传统腺癌区域的肿瘤细胞对全细胞角蛋白、细胞角蛋白7和上皮膜抗原呈弥漫性阳性。在微乳头区域，在细胞簇外部可见上皮膜抗原的膜性和周边胞质阳性，即所谓的“由内向外极性”模式，这是浸润性微乳头状癌的特征。在英文文献中，浸润性微乳头状癌在胃中非常罕见。
