Shimoda Masayuki, Okada Yasunori, Hayashi Yuichiro, Hatano Satoshi, Kawakubo Hirofumi, Omori Tai, Ishii Seiichiro, Sugiura Hitoshi
Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
Pathol Int. 2008 Aug;58(8):513-7. doi: 10.1111/j.1440-1827.2008.02265.x.
Reported herein is the case of a 74-year-old man with an unusual gastric carcinoma that developed at the lesser curvature of the stomach. The tumor consisted of small clusters of carcinoma cells surrounded by clear spaces, with histopathology similar to invasive micropapillary carcinoma (IMPC) of the breast. The carcinoma cells, which had downregulation of E-cadherin expression, invaded the subserous tissue and metastasized to the perigastric lymph nodes. IMPC, an unusual subtype of invasive breast carcinoma, is known to have frequent lymph node metastases, resulting in a poor clinical outcome. Although IMPC has been reported in breast, urinary bladder, ureter, lung, salivary gland and colon, to the best of the authors' knowledge this is the first report of IMPC arising in the stomach. Presented here are the clinicopathological features of primary IMPC of the stomach.
本文报道了一例74岁男性患者，其胃部小弯处发生了一种罕见的胃癌。肿瘤由小簇癌细胞组成，周围有透明间隙，组织病理学类似于乳腺浸润性微乳头状癌（IMPC）。癌细胞E-钙黏蛋白表达下调，侵犯浆膜下组织并转移至胃周淋巴结。IMPC是浸润性乳腺癌的一种罕见亚型，已知其常有淋巴结转移，导致临床预后不良。尽管IMPC已在乳腺、膀胱、输尿管、肺、唾液腺和结肠中被报道，但据作者所知，这是首例发生于胃的IMPC报告。本文展示了胃原发性IMPC的临床病理特征。
