White Carrie R, Langston Cathy, Hohenhaus Ann E, Lamb Kenneth, Hackner Susan, Fox Philip R
Departments of Medicine, Bobst Hospital of The Animal Medical Center, New York City, NY, 10065.
Lamb Consulting, West Saint Paul, MN, 55118.
J Vet Emerg Crit Care (San Antonio). 2016 Jan-Feb;26(1):74-9. doi: 10.1111/vec.12409. Epub 2015 Oct 12.
To determine whether hypercoagulability in proteinuric dogs, defined by thromboelastography (TEG), is related to the degree of proteinuria, presence of systemic arterial hypertension, presence of hypoalbuminemia, or reduced antithrombin activity.
Prospective study of client-owned dogs. Data collected from each patient included signalment, body weight, urine protein-to-creatinine ratio (UPC), serum albumin concentration, TEG values, noninvasive arterial blood pressure, and AT activity. Hypercoagulability was diagnosed by TEG and odds ratios for other measurements were assessed by univariate logistic regression.
Urban referral center and teaching hospital.
Seventy-six dogs with protein-losing nephropathy (PLN) based on UPC, diagnosed between Oct 2009 and Oct 2012.
None.
The prevalence of hypercoagulability was 89%. No statistically significant associations were detected between hypercoagulability and UPC, serum albumin, noninvasive blood pressure, or AT activity (all P > 0.05). The prevalence of thromboembolism was 6.6%.
Hypercoagulability was prevalent in dogs with PLN but could not be predicted based upon the presence or degree of proteinuria, systemic arterial hypertension, hypoalbuminemia, or low AT activity. The prevalance of thromboembolism was low in this population with PLN.
通过血栓弹力图（TEG）确定蛋白尿犬的高凝状态是否与蛋白尿程度、全身性动脉高血压、低白蛋白血症或抗凝血酶活性降低有关。
对客户拥有的犬进行前瞻性研究。从每位患者收集的数据包括特征、体重、尿蛋白与肌酐比值（UPC）、血清白蛋白浓度、TEG值、无创动脉血压和抗凝血酶活性。通过TEG诊断高凝状态，并通过单变量逻辑回归评估其他测量指标的比值比。
城市转诊中心和教学医院。
2009年10月至2012年10月期间基于UPC诊断为失蛋白性肾病（PLN）的76只犬。
无。
高凝状态的患病率为89%。在高凝状态与UPC、血清白蛋白、无创血压或抗凝血酶活性之间未检测到统计学上的显著关联（所有P>0.05）。血栓栓塞的患病率为6.6%。
高凝状态在PLN犬中普遍存在，但无法根据蛋白尿的存在或程度、全身性动脉高血压、低白蛋白血症或抗凝血酶活性降低来预测。该PLN犬群中血栓栓塞的患病率较低。
