Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, United Kingdom.
J Vet Intern Med. 2024 Jan-Feb;38(1):228-237. doi: 10.1111/jvim.16973. Epub 2023 Dec 26.
Knowledge of additional risk factors for thrombotic disease (TD) among dogs with renal proteinuria is limited; these might differ for TD affecting the systemic arterial (AT), systemic venous (VT), and pulmonary circulation (PT).
HYPOTHESIS/OBJECTIVES: To compare signalment and clinicopathological data between dogs with renal proteinuria with or without TD, and between dogs with AT, VT, and PT.
One hundred fifty client-owned dogs with renal proteinuria, 50 of which had TD.
Retrospective case-controlled study. A database search (2004-2021) identified proteinuric dogs (UPC > 2) with and without TD. Clinicopathological data were obtained from the records. TD and non-TD (NTD) groups were compared by binary logistic regression, and AT, VT, and PT groups by multinomial regression. Normal data presented as mean ± SD, non-normal data presented as median [25th, 75th percentiles].
Cavalier King Charles Spaniels were overrepresented in the TD group (OR = 98.8, 95% CI 2.09-4671, P = .02). Compared to NTD cases, TD cases had higher concentration of neutrophils (11.06 [8.92, 16.58] × 10 /L vs 7.31 [5.63, 11.06] × 10 /L, P = .02), and lower concentration of eosinophils (0 [0, 0.21] × 10 /L vs 0.17 [0.04, 0.41] × 10 /L, P = .002) in blood, and lower serum albumin (2.45 ± 0.73 g/dL vs 2.83 ± 0.73 g/dL, P = .04). AT cases had higher serum albumin concentrations than VT cases (2.73 ± 0.48 g/dL vs 2.17 ± 0.49 g/dL, P = .03) and were older than PT cases (10.6 ± 2.6 years vs 7.0 ± 4.3 years, P = .008). VT cases were older (9.1 ± 4.2 years vs 7.0 ± 4.3 years, P = .008) and had higher serum cholesterol concentration (398 [309-692 mg/dL] vs 255 [155-402 mg/dL], P = .03) than PT cases.
Differences between thrombus locations could reflect differences in pathogenesis.
患有肾性蛋白尿的犬发生血栓性疾病（TD）的其他危险因素的知识有限；这些因素可能因影响全身动脉（AT）、全身静脉（VT）和肺循环（PT）的 TD 而有所不同。
假设/目的：比较有或无 TD 的肾性蛋白尿犬以及 AT、VT 和 PT 犬的特征和临床病理数据。
150 只患有肾性蛋白尿的患犬，其中 50 只为 TD 犬。
回顾性病例对照研究。通过数据库搜索（2004-2021 年），确定了 UPC＞2 的有或无 TD 的蛋白尿犬。从病历中获取临床病理数据。通过二元逻辑回归比较 TD 组和非 TD（NTD）组，通过多项回归比较 AT、VT 和 PT 组。正态数据表示为均值±标准差，非正态数据表示为中位数[25 分位，75 分位]。
与 NTD 病例相比，TD 病例中更常见的品种是骑士查理王小猎犬（OR＝98.8，95％CI 2.09-4671，P＝.02）。TD 病例的血液中性粒细胞浓度更高（11.06[8.92，16.58]×10 3 /L 比 7.31[5.63，11.06]×10 3 /L，P＝.02），嗜酸性粒细胞浓度更低（0[0，0.21]×10 3 /L 比 0.17[0.04，0.41]×10 3 /L，P＝.002），血清白蛋白浓度更低（2.45±0.73 g/dL 比 2.83±0.73 g/dL，P＝.04）。AT 病例的血清白蛋白浓度高于 VT 病例（2.73±0.48 g/dL 比 2.17±0.49 g/dL，P＝.03），且年龄大于 PT 病例（10.6±2.6 岁比 7.0±4.3 岁，P＝.008）。VT 病例的年龄较大（9.1±4.2 岁比 7.0±4.3 岁，P＝.008），且胆固醇浓度较高（398[309-692 mg/dL]比 255[155-402 mg/dL]，P＝.03）。
血栓位置的差异可能反映了发病机制的差异。
