Vlaminck Johnny, Fischer Peter U, Weil Gary J
Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, 4444 Forest Parkway, St. Louis, MO 63108, USA.
Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, 4444 Forest Parkway, St. Louis, MO 63108, USA.
Trends Parasitol. 2015 Nov;31(11):571-582. doi: 10.1016/j.pt.2015.06.007. Epub 2015 Oct 11.
Onchocerciasis (river blindness) is a major public health problem in sub-Saharan Africa. Major disease-control programs have greatly reduced both disease and infection prevalence by mass distribution of donated ivermectin. Recent studies have shown that local elimination was achieved in some areas following many years of ivermectin. The global health community has recently decided to build on these successes with a new program that aims to eliminate onchocerciasis. Diagnostic tests that were useful for identifying priority areas for disease prevention may not be adequate tools for elimination programs. This paper reviews available and emerging diagnostic tests for onchocerciasis and considers how they might be best employed during different stages of onchocerciasis elimination programs.
盘尾丝虫病（河盲症）是撒哈拉以南非洲地区的一个主要公共卫生问题。主要的疾病控制项目通过大规模分发捐赠的伊维菌素，大幅降低了疾病和感染的流行率。最近的研究表明，经过多年使用伊维菌素后，一些地区已实现了本地消除。全球卫生界最近决定在这些成功的基础上开展一项新计划，旨在消除盘尾丝虫病。对确定疾病预防重点区域有用的诊断测试可能并不足以作为消除计划的工具。本文综述了现有的和新出现的盘尾丝虫病诊断测试，并考虑了在盘尾丝虫病消除计划的不同阶段如何能最佳地使用这些测试。
