Althoff J, Grandjean C, Russell L, Pour P
J Natl Cancer Inst. 1977 Feb;58(2):439-42. doi: 10.1093/jnci/58.2.439.
Vinylethylnitrosamine (VEN), an alpha-beta unsaturated analogue of diethylnitrosamine (DEN), which may be formed by the enzymic conversion necessary for carcinogenesis, was synthesized and its biologic effect was examined by sc administration to Syrian hamsters. Distribution studies showed that the maximum amount of unaltered compound was found in various tissues 45 minutes after injection. The chemical was only partially excreted unchanged after 5 hours. Weekly treatment for life resulted in high incidence of malignant respiratory tract neoplasms with short latencies and in tumors of the upper digestive tract and pancreas. The effects of VEN were compared to those of the assumed parent compound, DEN.
乙烯基乙基亚硝胺（VEN）是二乙基亚硝胺（DEN）的α-β不饱和类似物，它可能通过致癌过程中所需的酶促转化形成。合成了VEN，并通过皮下注射给叙利亚仓鼠来研究其生物学效应。分布研究表明，注射后45分钟，在各种组织中发现未改变的化合物的量最大。5小时后，该化学物质仅部分以未改变的形式排泄。终身每周治疗导致恶性呼吸道肿瘤的高发病率，潜伏期短，以及上消化道和胰腺肿瘤。将VEN的作用与假定的母体化合物DEN的作用进行了比较。
