乙烯基乙基亚硝胺对叙利亚金仓鼠的致癌性。
Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters.
作者信息
Green U, Althoff J
出版信息
J Cancer Res Clin Oncol. 1982;102(3):227-33. doi: 10.1007/BF00411342.
Abstract
Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract where a positive dose-response relationship was established for neoplastic growth.
摘要
叙利亚金黄地鼠每周皮下注射剂量为5.0、2.5、1.25或0.63毫克/千克体重的乙烯基亚硝基胺（VEN）。随着剂量水平的增加，平均存活时间缩短，肿瘤多发性增加，总肿瘤发生率也增加，总肿瘤发生率在50%至100%之间。VEN作用的主要靶器官是呼吸道，在呼吸道建立了肿瘤生长的正剂量反应关系。
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