Wang Xin, Pinto-Duarte António, Behrens M Margarita, Zhou Xianjin, Sejnowski Terrence J
Howard Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093, USA.
Sci Rep. 2015 Oct 13;5:14964. doi: 10.1038/srep14964.
Distinctive features in sensory event-related potentials (ERPs) are endophenotypic biomarkers of psychiatric disorders, widely studied using electroencephalographic (EEG) methods in humans and model animals. Despite the popularity and unique significance of the mouse as a model species in basic research, existing EEG methods applicable to mice are far less powerful than those available for humans and large animals. We developed a new method for multi-channel epidural ERP characterization in behaving mice with high precision, reliability and convenience and report an application to time-domain ERP feature characterization of the Sp4 hypomorphic mouse model for schizophrenia. Compared to previous methods, our spatio-temporal ERP measurement robustly improved the resolving power of key signatures characteristic of the disease model. The high performance and low cost of this technique makes it suitable for high-throughput behavioral and pharmacological studies.
感觉事件相关电位（ERP）中的独特特征是精神疾病的内表型生物标志物，在人类和模型动物中广泛使用脑电图（EEG）方法进行研究。尽管小鼠作为基础研究中的模型物种很受欢迎且具有独特意义，但现有的适用于小鼠的EEG方法远不如适用于人类和大型动物的方法强大。我们开发了一种新方法，用于在行为小鼠中高精度、可靠且方便地进行多通道硬膜外ERP表征，并报告了该方法在精神分裂症Sp4低表达小鼠模型的时域ERP特征表征中的应用。与以前的方法相比，我们的时空ERP测量显著提高了疾病模型关键特征的分辨能力。该技术的高性能和低成本使其适用于高通量行为和药理学研究。
