TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1.
作者信息
White Jennell C, Pawar Amrita, Fu Gratiana, Cui Shuaiying, Tavernier Fitz, Hamid Mariam, Harro David, Giacherio Donald, Campbell Andrew D, Hines Patrick C
机构信息
Wayne State University School of Medicine, Department of Pediatrics, United States.
C. S. Mott Children's Hospital, Division of Pediatric Hematology/Oncology, United States.
出版信息
Blood Cells Mol Dis. 2015 Dec;55(4):316-7. doi: 10.1016/j.bcmd.2015.07.003. Epub 2015 Jul 6.
Abstract
摘要
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TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1.在人源化镰状细胞病小鼠模型中TR2/TR4的过表达降低了红细胞与血管细胞黏附分子-1的黏附。
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本文引用的文献
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Increased erythrocyte adhesion to VCAM-1 during pulsatile flow: Application of a microfluidic flow adhesion bioassay.搏动血流期间红细胞与血管细胞黏附分子-1的黏附增加：微流控流动黏附生物测定法的应用
Clin Hemorheol Microcirc. 2015;60(2):201-13. doi: 10.3233/CH-141847.
2
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes.在镰状细胞病小鼠中强制表达 TR2/TR4 可增强胎儿血红蛋白的合成并减轻疾病表型。
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18808-13. doi: 10.1073/pnas.1104964108. Epub 2011 Oct 31.
3
Fetal hemoglobin in sickle cell disease: relationship to erythrocyte phosphatidylserine exposure and coagulation activation.
Blood. 2000 Aug 1;96(3):1119-24.
4
Hydroxyurea therapy decreases the in vitro adhesion of sickle erythrocytes to thrombospondin and laminin.羟基脲疗法可降低镰状红细胞在体外与血小板反应蛋白和层粘连蛋白的黏附。
Br J Haematol. 2000 May;109(2):322-7. doi: 10.1046/j.1365-2141.2000.02040.x.
5
6
7
Erytrocyte adherence to endothelium as a determinant of vasocclusive severity in sickle cell disease.红细胞与内皮细胞的黏附作为镰状细胞病血管闭塞严重程度的一个决定因素。
Trans Assoc Am Physicians. 1980;93:94-9.
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