健康男性红细胞的胰岛素结合及红细胞膜磷脂的脂肪酸组成
Insulin binding to erythrocytes and fatty acid composition of erythrocyte membrane phospholipids in healthy men.
作者信息
Pelikánová T, Kohout M, Hilgertová J, Rase J, Farská I, Válek J
机构信息
Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
出版信息
Clin Chim Acta. 1989 Feb 15;179(2):197-200. doi: 10.1016/0009-8981(89)90167-8.
The relationship between specific insulin binding to insulin receptors on erythrocytes and erythrocyte membrane phospholipid fatty acid pattern was evaluated in 11 healthy men. A significant negative correlation between insulin binding and the proportion of w-6 family essential fatty acids, especially linoleic acid (r = -0.82, p less than 0.01) and arachidonic acid (r = -0.73, p less than 0.05) in erythrocyte membrane was found. On the other hand significant positive correlation between insulin binding and the content of nonessential fatty acids (r = +0.65, p less than 0.05) was seen. Data presented support the hypothesis that the fatty acid composition of membrane phospholipids may modify properties of insulin receptors.
在11名健康男性中评估了红细胞上胰岛素特异性结合与红细胞膜磷脂脂肪酸模式之间的关系。发现胰岛素结合与红细胞膜中ω-6族必需脂肪酸的比例，尤其是亚油酸（r = -0.82，p < 0.01）和花生四烯酸（r = -0.73，p < 0.05）之间存在显著负相关。另一方面，观察到胰岛素结合与非必需脂肪酸含量之间存在显著正相关（r = +0.65，p < 0.05）。所呈现的数据支持以下假设：膜磷脂的脂肪酸组成可能会改变胰岛素受体的特性。
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