Brajenović Nataša, Karačonji Irena Brčić, Bulog Aleksandar
a Analytical Toxicology and Mineral Metabolism Unit , Institute for Medical Research and Occupational Health , Zagreb , Croatia.
b Department of Environmental Health, Faculty of Medicine , University of Rijeka , Rijeka , Croatia.
J Toxicol Environ Health A. 2015;78(17):1133-6. doi: 10.1080/15287394.2015.1066286. Epub 2015 Aug 20.
Benzene, toluene, ethylbenzene, and isomeric xylenes (BTEX) are by-products of tobacco smoke and traffic emissions. The aim of this study was to determine the contribution of cigarette smoking to urinary levels of BTEX present in humans. Nicotine and cotinine, biomarkers of exposure to tobacco smoke, as well as BTEX, were measured in urine of smokers (n = 70) and nonsmokers (n = 65) using headspace solid-phase microextraction (HS-SPME) followed by gas chromatography-mass spectrometry (GC-MS). In smokers, a significant correlation was found between urinary BTEX levels and nicotine and cotinine. In addition, significant regression models with nicotine and cotinine as predictors showed that BTEX in smokers' urine was predominantly derived from exposure to tobacco smoke. In nonsmokers a weak correlation between BTEX and nicotine and cotinine was found in urine. Further, there was a lack of significant contribution of BTEX to urinary nicotine and cotinine concentrations in nonsmokers. Thus, it was presumed that vehicle exhaust was the main source of exposure to BTEX in nonsmokers.
苯、甲苯、乙苯和二甲苯异构体（BTEX）是烟草烟雾和交通排放的副产品。本研究的目的是确定吸烟对人体尿液中BTEX水平的影响。使用顶空固相微萃取（HS-SPME）结合气相色谱-质谱联用（GC-MS）技术，对70名吸烟者和65名非吸烟者的尿液中的尼古丁、可替宁（烟草烟雾暴露的生物标志物）以及BTEX进行了测量。在吸烟者中，尿液BTEX水平与尼古丁和可替宁之间存在显著相关性。此外，以尼古丁和可替宁作为预测因子的显著回归模型表明，吸烟者尿液中的BTEX主要来源于烟草烟雾暴露。在非吸烟者尿液中，BTEX与尼古丁和可替宁之间存在弱相关性。此外，BTEX对非吸烟者尿液中尼古丁和可替宁浓度的贡献不显著。因此，推测机动车尾气是非吸烟者BTEX暴露的主要来源。
