Paun Alexandra, Danska Jayne S
Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Curr Opin Immunol. 2015 Dec;37:34-9. doi: 10.1016/j.coi.2015.09.004.
The trillions of microorganisms populating the mammalian mucosal surfaces (i.e. the microbiome) participate in the development and function of the host immune system that acts to balance clearance of pathogens with tolerance of beneficial commensals. Recent advances in mucosal immunology and culture-independent sequencing of microbial communities provide support for the hypothesis that the alterations in commensal microbiota alter the host immune response and can enhance risk for autoimmune disease in distant organs. Further explorations of the host-microbiota relationship will improve our understanding of autoimmune disorders and facilitate the discovery of a bacterial-based immunomodulators.
存在于哺乳动物黏膜表面的数万亿微生物（即微生物组）参与宿主免疫系统的发育和功能，该系统旨在平衡病原体清除与有益共生菌的耐受性。黏膜免疫学和微生物群落非培养测序技术的最新进展支持了这样一种假说，即共生微生物群的改变会改变宿主免疫反应，并可能增加远处器官发生自身免疫性疾病的风险。对宿主-微生物群关系的进一步探索将增进我们对自身免疫性疾病的理解，并有助于发现基于细菌的免疫调节剂。
