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现代择期关节置换术后诊断为院内肺栓塞患者的一年全因死亡率较低,且不受放射学严重程度的影响。

One-Year All-Cause Mortality of Patients Diagnosed as Having In-Hospital Pulmonary Embolism After Modern Elective Joint Arthroplasty Is Low And Unaffected By Radiologic Severity.

作者信息

Gonzalez Della Valle Alejandro, Lee Yuo-Yu, Saboeiro Gregory, Konin Gabrielle P, Endo Yoshimi, Robador Nicolas, Di Nallo Martin, Westrich Geoffrey H, Salvati Eduardo A

机构信息

Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York.

出版信息

J Arthroplasty. 2016 Feb;31(2):473-9. doi: 10.1016/j.arth.2015.09.006. Epub 2015 Sep 24.

Abstract

BACKGROUND

We studied the 1-year complication rate of patients diagnosed as having a pulmonary embolism (PE) after elective total hip arthroplasty (THA) and total knee arthroplasty (TKA) surgery and the distribution of emboli in the pulmonary circulation, and determined if a relationship exists between the location of the PE and age, gender, body mass index, preoperative predisposing factors, American Society of Anesthesiology classification, type of surgery, prophylaxis, hospital stay, transfer to a higher level of care, and mortality.

METHODS

Two hundred sixty-nine patients who developed an in-hospital PE proved by computed tomography pulmonary angiography after elective THA or TKA between 2005 and 2012 were studied.

RESULTS

The most proximal location of the emboli was central in 62, segmental in 139, and subsegmental in 68. Nineteen patients (7%) developed a bleeding complication during PE treatment. Twenty-nine patients (11%) were readmitted during the first year. Two patients (0.74%) died: one had a segmental PE after TKA. He died 11 months after surgery due to an autopsy-proven sepsis. The second patient developed a segmental PE after THA. She was anticoagulated, developed an intracranial bleed, and died 8 months after surgery. Multivariate analysis showed that demographic variables, American Society of Anesthesiology class, preoperative comorbidities (with the exception of arrhythmia), and the presence of preoperative predisposing factors had no effect in the location of the PE.

CONCLUSION

The 1-year mortality rate of these patients is low. Death can be caused by bleeding complications secondary to anticoagulation or by unrelated conditions. This information may aid clinicians while counseling patients who developed a PE after surgery, particularly those with small subsegmental emboli.

摘要

背景

我们研究了择期全髋关节置换术(THA)和全膝关节置换术(TKA)后被诊断为肺栓塞(PE)患者的1年并发症发生率以及肺循环中栓子的分布情况,并确定PE的位置与年龄、性别、体重指数、术前诱发因素、美国麻醉医师协会分级、手术类型、预防措施、住院时间、转至更高护理级别及死亡率之间是否存在关联。

方法

对2005年至2012年间在择期THA或TKA术后经计算机断层扫描肺动脉造影证实发生院内PE的269例患者进行了研究。

结果

栓子最近端位置为中心型62例,节段型139例,亚段型68例。19例患者(7%)在PE治疗期间出现出血并发症。29例患者(11%)在第1年再次入院。2例患者(0.74%)死亡:1例在TKA术后发生节段型PE,术后11个月因尸检证实的败血症死亡。第2例患者在THA术后发生节段型PE,接受抗凝治疗后出现颅内出血,术后8个月死亡。多因素分析显示,人口统计学变量、美国麻醉医师协会分级、术前合并症(心律失常除外)及术前诱发因素的存在对PE的位置无影响。

结论

这些患者的1年死亡率较低。死亡可能由抗凝继发的出血并发症或无关疾病引起。这些信息可能有助于临床医生在为术后发生PE的患者提供咨询时,尤其是那些有小亚段栓子的患者。

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