国际卵巢肿瘤分析（IOTA）小组的简单描述符和简单规则：一项关于联合使用以描述附件包块的前瞻性研究。

Simple descriptors and simple rules of the International Ovarian Tumor Analysis (IOTA) Group: a prospective study of combined use for the description of adnexal masses.

作者信息

Peces Rama Almudena, Llanos Llanos María Carmen, Sánchez Ferrer María Luisa, Alcázar Zambrano Juan Luis, Martínez Mendoza Antonio, Nieto Díaz Aníbal

机构信息

Department of Obstetrics and Gynecology, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2015 Dec;195:7-11. doi: 10.1016/j.ejogrb.2015.07.010. Epub 2015 Aug 20.

DOI:10.1016/j.ejogrb.2015.07.010

PMID:26461961

Abstract

OBJECTIVE

External validation of the IOTA group's three-step diagnostic model (Strategy 1) and comparison with assessment by an expert sonographer (Strategy 2).

STUDY DESIGN

Prospective study in patients with persistent adnexal masses, in which an inexperienced sonographer performed transvaginal ultrasound applying simple descriptors (SD) and rules (SR) for classifying as benign or malignant. Any non-classifiable mass was then submitted to an expert examiner for subjective assessment (SA).

RESULTS

Eighty-one patients (mean age, 43; 27.2% postmenopausal) were included in this prospective study. Surgery was performed for 30 (8 malignant and 22 benign) masses; 51 masses were considered as benign and managed expectantly (they were assumed to be benign for statistical purposes). Diagnostic performance for Strategy 1 (SD+SR+SA) was sensitivity (SN): 87.5% (7/8, 95% CI, 47.3-99.7%) and specificity (SP): 100% (73/73, 95% CI, 95.1-100%). For Strategy 2 (SA only) it was SN 87.5% (7/8, 95% CI, 47.3-99.7%), SP 98.6% (72/73, 95% CI, 92.6-100%).

CONCLUSIONS

The three-step diagnostic strategy designed by the IOTA group for adnexal masses has a diagnostic performance comparable to that of subjective expert assessment and could be used as a triage method by nonexpert sonographers.

摘要

目的

对国际卵巢肿瘤分析（IOTA）小组的三步诊断模型（策略1）进行外部验证，并与专家超声医师的评估（策略2）进行比较。

研究设计

对持续性附件包块患者进行前瞻性研究，由一名经验不足的超声医师采用简单描述符（SD）和规则（SR）进行经阴道超声检查，以将包块分类为良性或恶性。然后将任何无法分类的包块提交给专家检查者进行主观评估（SA）。

结果

81例患者（平均年龄43岁；27.2%为绝经后患者）纳入本前瞻性研究。对30个包块（8个恶性和22个良性）进行了手术；51个包块被认为是良性的并进行观察处理（出于统计目的假定它们为良性）。策略1（SD+SR+SA）的诊断性能为敏感性（SN）：87.5%（7/8，95%可信区间，47.3-99.7%）和特异性（SP）：100%（73/73，95%可信区间，95.1-100%）。对于策略2（仅SA），SN为87.5%（7/8，95%可信区间，47.3-99.7%），SP为98.6%（72/73，95%可信区间，92.6-100%）。