Solanki Vrushti, Singh Pratibha, Sharma Charu, Ghuman Navdeep, Sureka Binit, Shekhar Shashank, Gothwal Meenakshi, Yadav Garima
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Department of Radiodiagnosis, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
J Midlife Health. 2020 Oct-Dec;11(4):217-223. doi: 10.4103/jmh.JMH_103_20. Epub 2021 Jan 21.
Accurate prediction of adnexal tumors preoperatively is critical for optimal management of ovarian cancers. The International Ovarian Tumor Analysis Algorithms (IOTA) is a newer tool to characterize adnexal masses as benign or malignant.
This study is aimed to predict malignancy in adnexal masses and differentiates benign from malignant, applying the sonography features of simple rules given by IOTA.
A prospective study was carried out at AIIMS Jodhpur for 1½ years. Women presenting with adnexal masses planned for surgery were recruited. Ultrasonography-transabdominal combined with transvaginal was done, and pelvic masses were characterized using IOTA simple rules. Patients underwent their planned surgery. Histopathology is considered the gold standard and was compared with the IOTA simple rules. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.
One hundred and seventy-four women were included in the study, of which the majority (82.75%) were benign, the rest being frankly malignant or borderline cancer. The sensitivity of IOTA is 96.6%, specificity of 92.3%, PPV of 72.5%, NPV of 99.2%, where indeterminate cases were considered malignant.
IOTA simple rule is an effective tool for identifying malignant adnexal masses. It also suggests that IOTA-simple rules can be used as a diagnostic criterion for differentiating adnexal masses into benign and malignant on an out-patient department basis.
术前准确预测附件肿瘤对于卵巢癌的最佳治疗至关重要。国际卵巢肿瘤分析算法（IOTA）是一种用于将附件包块区分为良性或恶性的较新工具。
本研究旨在应用IOTA给出的简单规则的超声特征来预测附件包块的恶性情况，并区分良性与恶性。
在焦特布尔全印医学科学研究所进行了一项为期1年半的前瞻性研究。招募计划接受手术的附件包块女性患者。进行经腹超声联合经阴道超声检查，并使用IOTA简单规则对盆腔包块进行特征描述。患者接受计划中的手术。组织病理学被视为金标准，并与IOTA简单规则进行比较。计算敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。
174名女性纳入研究，其中大多数（82.75%）为良性，其余为明显恶性或交界性癌症。IOTA的敏感性为96.6%，特异性为92.3%，PPV为72.5%，NPV为99.2%，其中不确定病例被视为恶性。
IOTA简单规则是识别恶性附件包块的有效工具。这也表明IOTA简单规则可作为在门诊将附件包块区分为良性和恶性的诊断标准。
